Coupling between Voltage Sensors and Activation Gate in Voltage-gated K+ Channels
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چکیده
منابع مشابه
Coupling between Voltage Sensors and Activation Gate in Voltage-gated K+ Channels
Current through voltage-gated K+ channels underlies the action potential encoding the electrical signal in excitable cells. The four subunits of a voltage-gated K+ channel each have six transmembrane segments (S1-S6), whereas some other K+ channels, such as eukaryotic inward rectifier K+ channels and the prokaryotic KcsA channel, have only two transmembrane segments (M1 and M2). A voltage-gated...
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BACKGROUND Halogenated inhaled anesthetics modulate voltage-gated ion channels by unknown mechanisms. RESULTS Biophysical analyses revealed novel activation of K(v) channels by the inhaled anesthetic sevoflurane. CONCLUSION K(v) channel activation by sevoflurane results from the positive allosteric modulation of activation gating. SIGNIFICANCE The unique activation of K(v) channels by sev...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2002
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.20028696